Glycyrrhiza is known as the king of all kinds of medicine. It is a kind of tonic medicine of traditional Chinese medicine. It is a kind of legume perennial herb. It can be divided into Glycyrrhiza uralensis, bulging Glycyrrhiza uralensis and Guangguo Glycyrrhiza uralensis. Its main rhizome is 1.5-2CM in diameter and 1.5-2m in length. It is mainly produced in the arid areas of northeast, North and Northwest China, and distributed between 30-40n. It is a wild plant. Harvest in spring and autumn, remove fibrous roots and dry in the sun. Slice thick, raw or honey.

 

Licorice has been used as medicine since ancient times. It has the effect of detoxification, anti-inflammatory and anti allergy. Its curative effect is well known. Modern pharmacological research shows that liquorice contains isoliquiritigenin, glycyrrhizin, dipotassium Glycyrrhizinate, glycyrrhetinic acid, glycyrrhetinine, glycyrrhizin metal salt (zinc, calcium, iron), glycyrrhizin, glycyrrhizin and asparagine, protein and a variety of amino acids, lipids, mannitol, glycyrrhizin, glycyrrhizin, fruit acid, vitamins, trace elements and other effective ingredients.

 

Physicochemical Properties of Dipotassium Glycyrrhizinate

INCI Name
：Dipotassium Glycyrrhizate

CAS No.:68797-35-3

Physical properties: White to light yellow solid powder

Structural Formula:

 

Physical and chemical properties of dipotassium glycyrrhizinate

 

-Anti inflammatory Effect

 

Two potassium glycyrrhizinate has Mineralocorticoid like action - sodium retention and potassium steroid (Glucocorticoid *) like sugar metabolism, but there is no side effect in long-term use.

 

Direct action: it is generally believed that the chemical structure of glycyrrhetinic acid in dipotassium glycyrrhizinate is similar to that of cortin. It can affect ion channels, activate or inhibit enzyme activity, regulate substance metabolism, and regulate the excitability of cholinergic nerve by acting on hormone receptor on cell membrane. The results showed that the permeability of capillary wall and cell membrane decreased, inflammatory exudation decreased, histamine and other toxic substances were inhibited, so as to play a good anti-inflammatory effect.

 

Indirect effect: glycyrrhetinic acid in dipotassium glycyrrhizinate inhibits the destruction of adrenocortical hormone in the body, so that its content in the blood increases correspondingly, thus enhancing the resistance of human body to inflammation.

 

-Antiallergic Effect

 

Glycyrrhizic acid and its potassium salt have good antiallergic effect, inhibit histamine production and skin redness and itching have good effect, especially for some anaphylactic shock. The basic unit between the stimulation of pruritus and the impulses of free nerve endings is a medium with physiological activity. Histamine is the material basis of pruritus. Any factors that stimulate mast cells can make mast cells degranulate and release histamine, which can lead to pruritus. Therefore, antihistamines and stable mast cells can be used to reduce histamine release in clinic, which can treat the common itching phenomenon. As a common concomitant disease of skin sensitivity, itching has the similar main allergen and action way with allergic reaction. Experiments show that dipotassium glycyrrhizinate can inhibit the occurrence of type I hypersensitivity reaction, which can greatly reduce the incidence of itching.

 

-Regulatory Immunity

 

Dipotassium glycyrrhizinate and glycyrrhetinic acid can significantly enhance the activity of natural killer cells (i.e. natural kill cell cells) in human body, and play an important role in regulating the immune function of human body.

 

Inspection Items	Standard
Character	This product is a kind of white or light yellow fine powder, odorless, with a special sweet taste
Identify	1 positive 2 positive
Clarity	It should be clarified
pH	5.0-6.0
Ammonia Residue	Positive Reaction
Tone	≤0.018
Loss on Drying	≤6.0%
Burning Residue (Dry Product Meter)	18.0-22.0%
Chloride	≤0.014%
Sulfate	≤0.029%
Content (Dry Product)	≥67.0%（HPLC,Shanghai provides secondary standard）
	≥96.0%（UV）

 

 

 

 

 

 

 

Usage Method:

 

Emulsification System: directly adding water phase, high temperature resistance

 

Gel System: directly added (ionic, slightly reducing viscosity).

 

Cleaning System: directly added.

 

Product Application of Dipotassium Glycyrrhizinate

 

 

RECIPEO Acne & Sebum Care Spotrs Gel

 

 

With superior germicidal efficacy

 

Add "salicylic acid" and "dipotassium glycyrrhizinate derivative" which have the effect of removing horn suppository and anti-inflammatory to directly concentrate on the parts with acne. The non allergic and oil-free formula will make you more at ease.

AQUALABEL WHITE UP BASE NATURAL

 

1. Prevent UV damage and stain (SPF24PA + +)

 

2. Inhibit the production of melanin, prevent color spots, repair the skin damaged by the sun - containing high-purity vitamin C derivative and dipotassium glycyrrhizinate derivative.

 

Starting from cells, it can improve skin color, reduce skin metabolism, constantly discharge excess melanin, inhibit the generation of melanin, and restore bright and young skin color.